Probiotic Supplementation and High-Intensity Interval Training Modify Anxiety-Like Behaviors and Corticosterone in High-Fat Diet-Induced Obesity Mice

Evidence supports the role of exercise training and probiotics on reducing obesity. Considering relationship between obesity high-fat diet with anxiety indices, aim this study was to assess effect probiotic supplementation high-intensity interval (HIIT) anxiety-like behaviors, corticosterone indices in (HFD)-induced mice. Thirty male adult C57BL/6 mice were randomly divided into five groups: (1) Control normal (CON), (2) High-fat (HFD), (3) HFD + (HT), (4) supplement (HP) (5) +probiotics (HTP). Exercise consisted 8 weeks programs. Probiotics included 0.2 mL Lactobacillus rhamnosus GG. Anxiety-like behaviors measured by open field (OF) Elevated plus maze (EPM). OF EPM tests, visceral fat mass (VFM) measurement, blood sampling for performed after intervention. Bodyweight at different stages during regime increased bodyweight, VFM, serum levels (p < 0.05). HIIT, their combination, decreased improved behavior The a combination HIIT most more than each one separately 0.5). supplements or above all may have beneficial effects indices.